Evaluation of the early phase of Bell’s palsy using 3 T MRI

作者: Hartmut Peter Burmeister , Pascal Andreas Thomas Baltzer , Gerd Fabian Volk , Carsten Michael Klingner , Anke Kraft

DOI: 10.1007/S00405-011-1498-X

关键词: PalsyCerebellopontine angleNeurosurgeryProspective cohort studyFacial nerveBell's palsyEdemaNuclear medicineMedicineSurgeryMagnetic resonance imaging

摘要: This prospective study on Bell’s palsy investigated the value of 3 T MRI as a diagnostic tool to evaluate pathophysiological changes (i.e. edema) facial nerve segments and possibility differentiate patients with high risk for incomplete recovery from who recover completely within 3 days after symptoms onset. For this institutional review board approved investigation, thirty (14 male, 16 female, mean age 44 years) underwent pre postcontrast cerebellopontine angle. T1-weighted imaging was performed (TR 20.0 ms, TE 2.46 ms, isotropic voxel size: 0.6 mm). Region-of-interest measurements were healthy paralyzed side. To obtain normalized values, signal intensity increase percentage (SIIP) values divided by contralateral results Signal examined compared using Wilcoxon Mann–Whitney U tests correlated clinical findings categorized House–Brackmann score. The lesion side showed significantly higher intensities in premeatal segment before contrast agent administration (P   0.05). According our results, early palsy-associated might also be related accumulation proteins not exclusively edema. However, enhancement quantification suitable distinguish different prognostic groups.

参考文章(31)
Donald H. Gilden, Bell's Palsy The New England Journal of Medicine. ,vol. 351, pp. 1323- 1331 ,(2004) , 10.1056/NEJMCP041120
Hartmut Peter Burmeister, Franziska Hause, Pascal Andreas Thomas Baltzer, Peter Schmidt, Gerd Fabian Volk, Orlando Guntinas-Lichius, Jan Sedlacik, Hans-Joachim Mentzel, Werner Alois Kaiser, Improvement of visualization of the intermediofacial nerve in the temporal bone using 3T magnetic resonance imaging: part 1: the facial nerve. Journal of Computer Assisted Tomography. ,vol. 33, pp. 782- 788 ,(2009) , 10.1097/RCT.0B013E31818DA6BB
T. Kinoshita, K. Ishii, T. Okitsu, T. Ogawa, T. Okudera, High-intensity facial nerve lesions on T2-weighted images in chronic persistent facial nerve palsy Neuroradiology. ,vol. 43, pp. 388- 392 ,(2001) , 10.1007/S002340000385
Georgios Kefalidis, Maria Riga, Paraskevi Argyropoulou, Michael Katotomichelakis, Charalampos Gouveris, Panos Prassopoulos, Vasilios Danielides, Is the width of the labyrinthine portion of the fallopian tube implicated in the pathophysiology of Bell's palsy?: A prospective clinical study using computed tomography The Laryngoscope. ,vol. 120, pp. 1203- 1207 ,(2010) , 10.1002/LARY.20896
H. J. SEDDON, THREE TYPES OF NERVE INJURY Brain. ,vol. 66, pp. 237- 288 ,(1943) , 10.1093/BRAIN/66.4.237
H. MEI LIU, LIN HSUE YANG, YU JEN YANG, Schwann Cell Properties: 3. C-fos Expression, bFGF Production, Phagocytosis and Proliferation During Wallerian Degeneration Journal of Neuropathology and Experimental Neurology. ,vol. 54, pp. 487- 496 ,(1995) , 10.1097/00005072-199507000-00002
Mee Hyun Song, Jinna Kim, Ju Hyun Jeon, Chang Il Cho, Eun Hye Yoo, Won-Sang Lee, Ho-Ki Lee, Clinical significance of quantitative analysis of facial nerve enhancement on MRI in Bell's palsy. Acta Oto-laryngologica. ,vol. 128, pp. 1259- 1265 ,(2008) , 10.1080/00016480801901659
Mitchell K. Schwaber, Theodore C. Larson, David L. Zealear, Jeff Creasy, Gadolinium-enhanced magnetic resonance imaging in Bell's palsy. Laryngoscope. ,vol. 100, pp. 1264- 1269 ,(1990) , 10.1288/00005537-199012000-00003
Naohito Hato, Hiroyuki Yamada, Hisashi Kohno, Shuichi Matsumoto, Nobumitsu Honda, Kiyofumi Gyo, Satoshi Fukuda, Yasushi Furuta, Fumio Ohtani, Hiroshi Aizawa, Masaru Aoyagi, Hiroo Inamura, Tsutomu Nakashima, Seiichi Nakata, Shingo Murakami, Jun Kiguchi, Koji Yamano, Taizo Takeda, Masashi Hamada, Kazuhiro Yamakawa, Valacyclovir and prednisolone treatment for Bell's palsy: a multicenter, randomized, placebo-controlled study. Otology & Neurotology. ,vol. 28, pp. 408- 413 ,(2007) , 10.1097/01.MAO.0000265190.29969.12
Maria Grosheva, Claus Wittekindt, Orlando Guntinas-Lichius, Prognostic Value of Electroneurography and Electromyography in Facial Palsy The Laryngoscope. ,vol. 118, pp. 394- 397 ,(2008) , 10.1097/MLG.0B013E31815D8E68