A prospective observational study of changes in renal function and cardiovascular risk following living kidney donation.
作者： G V. Ramesh Prasad , Deborah Lipszyc , Michael Huang , Michelle M. Nash , Lindita Rapi
DOI: 10.1097/TP.0B013E318188425B
关键词: Nephrectomy 、 Urinary system 、 Blood pressure 、 Kidney disease 、 Ambulatory blood pressure 、 Kidney transplantation 、 Urology 、 Kidney 、 Renal function 、 Medicine 、 Endocrinology 、 Internal medicine
摘要: The effect of unilateral nephrectomy on the cardiovascular risk profile living kidney donors has not been prospectively studied. We performed an observational cohort study 58 to 6 months postdonation for changes in 24-hr ambulatory blood pressure profiles, renal function, urine protein excretion, body mass index, glucose tolerance, and fasting lipid profiles. systolic average night-day ratio were unchanged from pre- (118.9+/-11 vs. 118.1+/-14 mm Hg, P=0.77; 0.87+/-0.07 0.87+/-0.09, P=0.68, respectively). Estimated glomerular filtration rate declined 91.9+/-16 61.6+/-12 mL/min/1.73 m2 (P<0.0001). Protein glucose, lipids unchanged. No significant differences noted between dippers nondippers either or postdonation. In summary, donation short term is safe. suggest further observation individuals with lower possible increased factors future.
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