Effects of developmental exposure to bisphenol A on spatial navigational learning and memory in rats: A CLARITY-BPA study

摘要: Bisphenol A (BPA) is a ubiquitous industrial chemical used in the production of wide variety items. Previous studies suggest BPA exposure may result neuro-disruptive effects; however, data are inconsistent across animal and human studies. As part Consortium Linking Academic Regulatory Insights on Toxicity (CLARITY-BPA), we sought to determine whether female male rats developmentally exposed demonstrated later spatial navigational learning memory deficits. Pregnant NCTR Sprague-Dawley were orally dosed from gestational day 6 parturition, offspring directly until weaning (postnatal 21). Treatment groups included vehicle control, three doses (2.5μg/kg body weight (bw)/day-[2.5], 25μg/kg bw/day-[25], 2500μg/kg bw/day-[2500]) 0.5μg/kg/day ethinyl estradiol (EE)-reference estrogen dose. At adulthood, 1/sex/litter was tested for seven days Barnes maze. The 2500 group sniffed more incorrect holes 7 than those 2.5 BPA, EE groups. females less likely control locate escape box allotted time (p value=0.04). Although exhibited prolonged latency, effect did not reach significance value=0.06), whereas males showed improved latency compared value=0.04), although this uncertain. No differences serum testosterone concentration detected any or treatment Current findings developmental disrupt aspects memory.