Therapeutic monoclonal antibody for sporotrichosis.

摘要: Sporotrichosis is a chronic subcutaneous mycosis that affects either humans or animals and occurs worldwide. This had been attributed to single etiological agent, Sporothrix schenckii. S. schenckii exhibits considerable genetic variability, where recently, was suggesting this taxon consists of complex species. caused by traumatic inoculation the fungus, which ubiquitous environmental saprophyte can be isolated from soil plant debris. The infection limited cutaneous forms but, occurrences more severe clinical were described, especially among immunocompromized individuals. immunological mechanisms involved in prevention control sporotrichosis are still not very well understood. Some works suggest cell-mediated immunity plays an important role protecting host against In contrast, humoral immune response protection fungus have studied detail. previous study, we showed antigens secreted induce specific infected animals, mainly 70-kDa molecules, indicating possible participation antibodies molecule control. other work our group, produced mAb glycoprotein order better understand effect passive immunization mice with Results significant reduction number CFU organs when injected before during infection. Similar results observed T-cell deficient used. Drugs choice treatment sporothrichosis require long periods frequently relapses observed, patients. strong induced makes it candidate for therapeutic vaccine