Curcumin acts anti-proliferative and pro-apoptotic in human meningiomas

摘要: Meningiomas, the most frequent benign intracranial and intraspinal types of tumors are normally removed by surgery. Complications can occur when tumor is critically localized cannot be completely or comorbidities mostly elder patients increase general surgical risk. Thus, alternate medical treatment concepts for therapy meningiomas would desirable. Curcumin, active ingredient spice plant Curcuma longa has shown anti-tumorigenic actions in many different therefore, its effect on growth apoptosis meningioma cells was studied present paper. In vitro, human Ben-Men-1 cell line a series 21 primary cultures with curcumin (1–20 μM) strongly reduced proliferation all cases dose dependent manner. Cell cycle analysis fluorescence-activated sorting showed arrest at G2/M phase, which confirmed demonstrating corresponding modulation proteins involved immunoblotting and/or confocal laser microscopy. High dosages (20, 50 induced significant as demonstrated morphological changes nuclei, DNA fragmentation, translocation membrane associated phosphatidyl serine induction apoptotic-acting cleaved caspase-3. Our results suggest that multi-targeting drug potent might therefore putative candidate pharmacological meningiomas.