Neurochemical consequences of status epilepticus induced in rats by coadministration of lithium and pilocarpine
作者： Richard S. Jope , Richard A. Morrisett
DOI: 10.1016/0014-4886(86)90200-1
关键词: Acetylcholine 、 Striatum 、 Chemistry 、 Choline transport 、 Pilocarpine 、 Choline 、 Internal medicine 、 Hippocampus 、 Endocrinology 、 Status epilepticus 、 Cholinergic 、 Developmental Neuroscience 、 Neurology
摘要: Status epilepticus was produced in rats by administering pilocarpine (30 mg/kg, s.c.) 16 h after treatment with LiCl (3 meq/kg, i.p.). After 35 min of status epilepticus, several parameters cholinergic activity were measured. Seizures had no effect on the vivo concentration acetylcholine or choline cerebellum, cortex, hippocampus, striatum. Synaptosomal high-affinity transport also not changed seizures Cortical slices from seizing elevated concentrations and released at a greater rate than did controls, but these effects seemed to be due reduction postmortem hydrolysis acetylcholine. 45calcium uptake during 2 60 s incubation different control rates tissue prepared rats. These results indicate that presynaptic is markedly altered continuous seizure induced lithium pilocarpine. In contrast, cyclic guanosine 5'-monophosphate above values 57 170%
elsevier.com
sci-hub.se 参考文章(30)
Surendra K. Puri, Paul Choma, Ladislav Volicer, Cyclic nucleotide levels in the rat striatum and cerebellum— Biochemical Pharmacology. ,vol. 27, pp. 2333- 2336 ,(1978) , 10.1016/0006-2952(78)90140-5
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Steven L. Cohen, Barbara J. Morley, O.Carter Snead, An EEG analysis of convulsive activity produced by cholinergic agents Progress in Neuro-Psychopharmacology. ,vol. 5, pp. 383- 388 ,(1981) , 10.1016/0364-7722(81)90089-8
Claude G. Wasterlain, Viliam Jonec, Cholinergic kindling of the amygdala requires the activation of muscarinic receptors Experimental Neurology. ,vol. 73, pp. 595- 599 ,(1981) , 10.1016/0014-4886(81)90294-6
Shih-Chia C. Lin, E. Leong Way, A high affinity Ca2+-ATPase in enriched nerve-ending plasma membranes. Brain Research. ,vol. 235, pp. 387- 392 ,(1982) , 10.1016/0006-8993(82)91018-6
S. W. Leslie, E. Barr, L. J. Chandler, Comparison of voltage-dependent 45Ca2+ uptake rates by synaptosomes isolated from rat brain regions. Journal of Neurochemistry. ,vol. 41, pp. 1602- 1605 ,(1983) , 10.1111/J.1471-4159.1983.TB00870.X
Shigenobu Kanba, Michael Pfenning, Elliott Richelson, Lithium ions inhibit function of lowbut not high-affinity muscarinic receptors of murine neuroblastoma cells (clone N1E-115) Psychopharmacology. ,vol. 86, pp. 413- 416 ,(1985) , 10.1007/BF00427901
John W. Olney, Taisija de Gubareff, Joann Labruyere, Seizure-related brain damage induced by cholinergic agents. Nature. ,vol. 301, pp. 520- 522 ,(1983) , 10.1038/301520A0
M. Honchar, J. Olney, W. Sherman, Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats. Science. ,vol. 220, pp. 323- 325 ,(1983) , 10.1126/SCIENCE.6301005
Ryoji Kobayashi, Victor S. Fang, A simple and sensitive competitive protein-binding assay for cyclic GMP. Biochemical and Biophysical Research Communications. ,vol. 67, pp. 493- 500 ,(1975) , 10.1016/0006-291X(75)90839-6