Cholinergic kindling of the amygdala requires the activation of muscarinic receptors

作者: Claude G. Wasterlain , Viliam Jonec

DOI: 10.1016/0014-4886(81)90294-6

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摘要: Abstract Daily injections of subconvulsive amounts carbamylcholine into the rat's amygdala resulted in progressive kindling epileptic seizures. This was dose dependent and blocked by muscarinic blockers not nicotinic blockers, suggesting that this model first step induction kindled seizures involves activation receptors.

参考文章(15)
D.J. Triggle, C.R. Triggle, Chemical pharmacology of the synapse ,(1976)
John B. Simpson, Aryeh Routtenberg, The subfornical organ and carbachol-induced drinking Brain Research. ,vol. 45, pp. 135- 152 ,(1972) , 10.1016/0006-8993(72)90221-1
Tamas Bartfai, Jan Anner, Marianne Schultzberg, Johan Montelius, Partial purification and characterization of a muscarinic acetylcholine receptor from rat cerebral cortex Biochemical and Biophysical Research Communications. ,vol. 59, pp. 725- 733 ,(1974) , 10.1016/S0006-291X(74)80040-9
Helen Vosu, Roy A. Wise, Cholinergic seizure kindling in the rat: Comparison of caudate, amygdala and hippocampus Behavioral Biology. ,vol. 13, pp. 491- 495 ,(1975) , 10.1016/S0091-6773(75)91109-8
T.-P. Lee, J. F. Kuo, P. Greengard, Role of Muscarinic Cholinergic Receptors in Regulation of Guanosine 3′:5′-Cyclic Monophosphate Content in Mammalian Brain, Heart Muscle, and Intestinal Smooth Muscle Proceedings of the National Academy of Sciences of the United States of America. ,vol. 69, pp. 3287- 3291 ,(1972) , 10.1073/PNAS.69.11.3287
Jerome Engel, Nansie S. Sharpless, Long-lasting depletion of dopamine in the rat amygdala induced by kindling stimulation Brain Research. ,vol. 136, pp. 381- 386 ,(1977) , 10.1016/0006-8993(77)90815-0
Graham V. Goddard, Analysis of avoidance conditioning following cholinergic stimulation of amygdala in rats. Journal of Comparative and Physiological Psychology. ,vol. 68, pp. 1- 18 ,(1969) , 10.1037/H0027504
A.S.V. BURGEN, C.R. HILEY, J.M. YOUNG, The properties of muscarinic receptors in mammalian cerebral cortex British Journal of Pharmacology. ,vol. 51, pp. 279- 285 ,(1974) , 10.1111/J.1476-5381.1974.TB09658.X