Characterization of lithium potentiation of pilocarpine-induced status epilepticus in rats

摘要: Subcutaneous administration of pilocarpine to rats that were pretreated with a small dose lithium chloride results in the evolution generalized convulsive status epilepticus. The production epilepticus is absolutely reproducible, has very consistent time onset (22 min), duration several hours, and extremely severe high mortality rate. Experimental show this animal model epilepticus: (i) requires activation muscarinic receptors because initiation seizures blocked by atropine; (ii) presynaptic cholinergic activity it attenuated hemicholinium-3; (iii) recruits noncholinergic cells when established not altered atropine administration; (iv) pretreatment diazepam ongoing are terminated diazepam, similar certain forms humans. reproducibility, prolonged nature, involvement clearly defined neurochemical system as triggering mechanism, i.e., activation, makes potentially valuable