Modeling precision treatment of breast cancer

作者: James E Korkola , Malachi Griffith , Joe S Hur , Nam Huh , Jongsuk Chung

DOI: 10.1186/GB-2013-14-10-R110

关键词: Clinical trialBiologySystems biologyGenomicsProteomicsHuman geneticsBreast cancerGene expression profilingRegulation of gene expressionBioinformatics

摘要: … We assembled a collection of 84 breast cancer cell lines composed of 35 luminal, 27 basal, 10 claudin-low, 7 normal-like, 2 matched normal cell lines, and 3 of unknown subtype (…

参考文章(37)
Joanne L. Blum, Stephen E. Jones, Aman U. Buzdar, Patricia Mucci LoRusso, Irene Kuter, Charles Vogel, Bruno Osterwalder, Hans-Ulrich Burger, Cheryl Stoner Brown, Tom Griffin, Multicenter Phase II Study of Capecitabine in Paclitaxel-Refractory Metastatic Breast Cancer Journal of Clinical Oncology. ,vol. 17, pp. 485- 493 ,(1999) , 10.1200/JCO.1999.17.2.485
Kate L. Jeffrey, Montserrat Camps, Christian Rommel, Charles R. Mackay, Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses Nature Reviews Drug Discovery. ,vol. 6, pp. 391- 403 ,(2007) , 10.1038/NRD2289
Hong Joo Kim, Dafna Bar-Sagi, Modulation of signalling by Sprouty: a developing story. Nature Reviews Molecular Cell Biology. ,vol. 5, pp. 441- 450 ,(2004) , 10.1038/NRM1400
Q.-S. Zhu, W. Ren, B. Korchin, G. Lahat, A. Dicker, Y. Lu, G. Mills, R. E. Pollock, D. Lev, Soft Tissue Sarcoma Cells Are Highly Sensitive to AKT Blockade: A Role for p53-Independent Up-regulation of GADD45α Cancer Research. ,vol. 68, pp. 2895- 2903 ,(2008) , 10.1158/0008-5472.CAN-07-6268
J.A.K. Suykens, J. De Brabanter, L. Lukas, J. Vandewalle, Weighted least squares support vector machines: robustness and sparse approximation Neurocomputing. ,vol. 48, pp. 85- 105 ,(2002) , 10.1016/S0925-2312(01)00644-0
AD Barker, CC Sigman, GJ Kelloff, NM Hylton, DA Berry, LJ Esserman, I‐SPY 2: An Adaptive Breast Cancer Trial Design in the Setting of Neoadjuvant Chemotherapy Clinical Pharmacology & Therapeutics. ,vol. 86, pp. 97- 100 ,(2009) , 10.1038/CLPT.2009.68
Christina Curtis, Sohrab P Shah, Suet-Feung Chin, Gulisa Turashvili, Oscar M Rueda, Mark J Dunning, Doug Speed, Andy G Lynch, Shamith Samarajiwa, Yinyin Yuan, Stefan Gräf, Gavin Ha, Gholamreza Haffari, Ali Bashashati, Roslin Russell, Steven McKinney, METABRIC Group Co-chairs Caldas Carlos Aparicio Samuel saparicio@ bccrc. ca 17 18 c, Writing committee Curtis† Christina 15 16 Shah Sohrab P. 17 18 Caldas Carlos Aparicio Samuel saparicio@ bccrc. ca 17 18 e, Steering committee Brenton James D. 15 16 Ellis Ian 19 Huntsman David 17 18 Pinder Sarah 20 Purushotham Arnie 20 Murphy Leigh 21 Caldas Carlos Aparicio Samuel saparicio@ bccrc. ca 17 18 j, British Columbia Cancer Agency Aparicio Samuel saparicio@ bccrc. ca 17 18 b Chia Steven 18 Gelmon Karen 18 Huntsman David 17 18 McKinney Steven 17 18 Speers Caroline 18 Turashvili Gulisa 17 18 Watson Peter 17 18 21, University of Nottingham Ellis Ian 19 Blamey Roger 19 Green Andrew 19 Macmillan Douglas 19 Rakha Emad 19, King’s College London Purushotham Arnie 20 Gillett Cheryl 20 Grigoriadis Anita 20 Pinder Sarah 20 de Rinaldis Emanuele 20 Tutt Andy 20, Manitoba Institute of Cell Biology Murphy Leigh 21 Parisien Michelle 21 Troup Sandra 21, British Columbia Cancer Agency Aparicio Samuel saparicio@ bccrc. ca 17 18 b Turashvili Gulisa 17 18 Bell Lynda 18 Chow Katie 18 Gale Nadia 18 Huntsman David 17 18 Kovalik Maria 18 Ng Ying 18 Prentice Leah 18, British Columbia Cancer Agency Aparicio Samuel saparicio@ bccrc. ca 17 18 b Shah Sohrab P. 17 18 Bashashati Ali 17 Ha Gavin 17 Haffari Gholamreza 17 McKinney Steven 17 18, None, The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups Nature. ,vol. 486, pp. 346- 352 ,(2012) , 10.1038/NATURE10983
Ingvar Ferby, Markus Reschke, Oliver Kudlacek, Pjotr Knyazev, Guido Pantè, Kerstin Amann, Wolfgang Sommergruber, Norbert Kraut, Axel Ullrich, Reinhard Fässler, Rüdiger Klein, Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation Nature Medicine. ,vol. 12, pp. 568- 573 ,(2006) , 10.1038/NM1401
Jordi Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A Margolin, Sungjoon Kim, Christopher J Wilson, Joseph Lehár, Gregory V Kryukov, Dmitriy Sonkin, Anupama Reddy, Manway Liu, Lauren Murray, Michael F Berger, John E Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jané-Valbuena, Felipa A Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H Engels, Jill Cheng, Guoying K Yu, Jianjun Yu, Peter Aspesi, Melanie De Silva, Kalpana Jagtap, Michael D Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C Onofrio, Ted Liefeld, Laura MacConaill, Wendy Winckler, Michael Reich, Nanxin Li, Jill P Mesirov, Stacey B Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E Myer, Barbara L Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L Harris, Matthew Meyerson, Todd R Golub, Michael P Morrissey, William R Sellers, Robert Schlegel, Levi A Garraway, None, The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity Nature. ,vol. 483, pp. 603- 607 ,(2012) , 10.1038/NATURE11003
Nayoung Kim, Ningning He, Changsik Kim, Fan Zhang, Yiling Lu, Qinghua Yu, Katherine Stemke-Hale, Joel Greshock, Richard Wooster, Sukjoon Yoon, Gordon B Mills, Systematic analysis of genotype‐specific drug responses in cancer International Journal of Cancer. ,vol. 131, pp. 2456- 2464 ,(2012) , 10.1002/IJC.27529