Patterns of Surveillance Following Curative Intent Therapy for Gastroesophageal Cancer

作者: Renata D. Peixoto , Howard J. Lim , Haerin Kim , Ahmad Abdullah , Winson Y. Cheung

DOI: 10.1007/S12029-014-9601-3

关键词: EndoscopyCohortMedicineInternal medicineDiseaseProportional hazards modelEsophageal cancerPopulationCancerRadiation therapyOncology

摘要: Our aims were to examine surveillance strategies after curative treatment of early gastroesophageal (GE) cancer and evaluate the impact different approaches on outcomes. A total 292 patients with non-metastatic GE who referred BC Cancer Agency from 2001 2010 for intent analyzed. Surveillance practices classified into following: cohort 1 (discharge general practitioner), 2 (follow-up by oncologist clinical assessments), 3 (specialist follow-up laboratory investigations), 4 imaging or endoscopy). Outcomes compared across cohorts using Kaplan–Meier methods Cox regression. In total, median age was 63 years 76 % men. Eighty-nine (30 %), 18 (6 %), 32 (11 %), 152 (53 %) 4, respectively. Patients primary lesions involving distal esophagus more likely undergo intensive which involved studies endoscopic procedures (p = 0.001). Individuals affected specific histological subtypes, such as squamous cell carcinoma signet variant, those whose disease managed definitive chemoradiotherapy without surgery also inclined receive (p = 0.008 p = 0.001, respectively) There no significant differences in overall (p = 0.34) relapse-free survival (p = 0.59) among strategies, even adjusting measured prognostic factors. this population-based analysis, outcomes comparable irrespective strategy. Intensive routine endoscopy may not be justified given financial implications these costly investigations.

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