p38MAPK inhibition attenuates LPS-induced acute lung injury involvement of NF-κB pathway

摘要: The pathogenesis of acute lung injury/acute respiratory distress syndrome (ARDS) is complex and involves multiple signal transduction processes. It believed that p38MAPK (mitogen-activated protein kinase) one the most kinases in inflammatory signaling. At present study, we demonstrated role lipopolysaccharide (LPS)-induced injury with pharmacologic inhibition by SB203580. SB203580, specific inhibitor, was injected (10 mg/kg, i.v.) 30 min before LPS administration (5 i.v.). hematoxylin-eosin staining tissues showed significantly attenuated pulmonary responses induced LPS. Moreover, SB203580 can also inhibit cytokine release, reduce mortality rate LPS-induced injury. Further, western blot analysis activation NF-kappaB, which associated IkappaBalpha degradation cytoplasm. These data suggest signaling may be involved mechanisms