Role of p38 MAP kinase in the development of acute lung injury.

摘要: Acute lung injury (ALI) is characterized by an intense pulmonary inflammatory response, in which neutrophils play a central role. The p38 mitogen-activated protein kinase pathway involved the regulation of stress-induced cellular functions and appears to be important modulating neutrophil activation, particularly response endotoxin. Although has potent effects on under vitro conditions, there relatively little information concerning role affecting neutrophil-driven responses vivo. To examine this issue, we treated mice with inhibitor SB203580 then examined parameters activation acute after hemorrhage or endotoxemia. was activated endotoxemia, inhibition did not decrease accumulation lungs development edema these conditions. Similarly, increased production proinflammatory cytokines NF-κB induced endotoxemia diminished inhibition. These results indicate that does have ALI either