Antibiotics Cure Anthrax in Animal Models

摘要: Respiratory anthrax, in the absence of early antibiotic treatment, is a fatal disease. This study aimed to test efficiency therapy curing infected animals and those sick with anthrax. Postexposure prophylaxis (24 h postinfection [p.i.]) guinea pigs intranasally Bacillus anthracis Vollum spores doxycycline, ofloxacin, imipenem, gentamicin conferred protection. However, upon termination died from respiratory Combined treatment antibiotics active vaccination protective antigen-based vaccine leads full protection even after cessation treatment. Delaying initiation administration over 24 p.i. resulted anthrax exhibiting various degrees bacteremia toxemia. Treatment doxycycline or ciprofloxacin cured rabbits levels up 10(5) CFU/ml. Addition anti-protective antigen (PA) antibodies augmented protection, allowing cure 10- 20-fold-higher levels, 7 × CFU/ml 2 10(6) CFU/ml, respectively. monoclonal anti-PA antibody rescued 4 During administration, all surviving developed immune response against development disease subcutaneous challenge spores. In conclusion, these results demonstrate that can prevent respiratory-anthrax-infected establishment. A therapeutic time window 40 48 infection efficient antibiotic-mediated was observed.