An Expeditious and Efficient Synthesis of Highly Functionalized [1,6]-Naphthyridines under Catalyst-Free Conditions in Aqueous Medium

作者: Chhanda Mukhopadhyay , Paramita Das , Ray J. Butcher

DOI: 10.1021/OL201877V

关键词: ChemistryCombinatorial chemistryMalononitrileSolventMoietyOrganic chemistryAqueous mediumCatalysisAnhydrous

摘要: This is the first report of an innovative, one-pot, catalyst-free, pseudo-five-component synthesis 1,2-dihydro[1,6]naphthyridines from methyl ketones, amines, and malononitrile in ecofriendly solvent water. The protocol avoids use expensive catalysts, toxic organic solvents anhydrous condition. approach to naphthyridines presented herein offers for time unprecedented coupling which leads construction both nitrogen containing rings during without starting any nitrogen-containing heterocycle moiety.

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