作者: Chhanda Mukhopadhyay , Paramita Das , Ray J. Butcher
DOI: 10.1021/OL201877V
关键词: Chemistry 、 Combinatorial chemistry 、 Malononitrile 、 Solvent 、 Moiety 、 Organic chemistry 、 Aqueous medium 、 Catalysis 、 Anhydrous
摘要: This is the first report of an innovative, one-pot, catalyst-free, pseudo-five-component synthesis 1,2-dihydro[1,6]naphthyridines from methyl ketones, amines, and malononitrile in ecofriendly solvent water. The protocol avoids use expensive catalysts, toxic organic solvents anhydrous condition. approach to naphthyridines presented herein offers for time unprecedented coupling which leads construction both nitrogen containing rings during without starting any nitrogen-containing heterocycle moiety.