Apoptolidin: induction of apoptosis by a natural product.
作者： Peter T. Daniel , Ulrich Koert , Julia Schuppan
关键词: Programmed cell death 、 Cell 、 Caspase 、 Apoptosome 、 Cell biology 、 Morphogenesis 、 Intrinsic apoptosis 、 Mitochondrion 、 Apoptosis 、 Chemistry
摘要: Apoptolidin is a natural product that selectively induces apoptosis in several cancer cell lines. Apoptosis, programmed death, biological key pathway for regulating homeostasis and morphogenesis. Apoptotic misregulations are connected with diseases, particular cancer. The extrinsic way to leads through death ligands receptors the activiation of caspase cascade, which results proteolytic degradation architecture. intrinsic transmits signals internal cellular damage mitochondrion, loses its structural integrity, forms an apoptosome initiates cascade. Compounds regulate high medical significance. Many products apoptotic pathways, apoptolidin one them. known synthetic routes described compared this Review. Selected further introduced briefly.
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