FLAXSEED OIL INDUCES APOPTOSIS IN THE AGGRESSIVE MURINE MELANOMA CELL LINE B16-BL6

A. Samundeeswari, M. Joyce Nirmala, P. Deepa Sankar, Natural plant resources in anti-cancer therapy-A review Research in Plant Biology. ,vol. 1, pp. 1- 14 ,(2011)

Holy Nadia Rabetafika, Vinciane Van Remoortel, Sabine Danthine, Michel Paquot, Christophe Blecker, Flaxseed proteins: food uses and health benefits International Journal of Food Science and Technology. ,vol. 46, pp. 221- 228 ,(2011) , 10.1111/J.1365-2621.2010.02477.X

Kevin L. Fritsche, Patricia V. Johnston, Effect of Dietary α-Linolenic Acid on Growth, Metastasis, Fatty Acid Profile and Prostaglandin Production of Two Murine Mammary Adenocarcinomas The Journal of Nutrition. ,vol. 120, pp. 1601- 1609 ,(1990) , 10.1093/JN/120.12.1601

Leonard A. Sauer, Robert T. Dauchy, David E. Blask, Jean A. Krause, Leslie K. Davidson, Erin M. Dauchy, Eicosapentaenoic Acid Suppresses Cell Proliferation in MCF-7 Human Breast Cancer Xenografts in Nude Rats via a Pertussis Toxin–Sensitive Signal Transduction Pathway Journal of Nutrition. ,vol. 135, pp. 2124- 2129 ,(2005) , 10.1093/JN/135.9.2124

A.P Simopoulos, The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomedicine & Pharmacotherapy. ,vol. 56, pp. 365- 379 ,(2002) , 10.1016/S0753-3322(02)00253-6

Peter M. Fischer, David M. Glover, David P. Lane, Targeting the cell cycle Drug Discovery Today: Therapeutic Strategies. ,vol. 1, pp. 417- 423 ,(2004) , 10.1016/J.DDSTR.2004.11.014

Kin S. Lam, New aspects of natural products in drug discovery. Trends in Microbiology. ,vol. 15, pp. 279- 289 ,(2007) , 10.1016/J.TIM.2007.04.001

D Rose, Omega-3 fatty acids as cancer chemopreventive agents. Pharmacology & Therapeutics. ,vol. 83, pp. 217- 244 ,(1999) , 10.1016/S0163-7258(99)00026-1

Diana L Tallman, Carla G Taylor, Effects of dietary fat and zinc on adiposity, serum leptin and adipose fatty acid composition in C57BL/6J mice. Journal of Nutritional Biochemistry. ,vol. 14, pp. 17- 23 ,(2003) , 10.1016/S0955-2863(02)00228-0

T. H. Malasanos, P. W. Stacpoole, Biological Effects of ω-3 Fatty Acids in Diabetes Mellitus Diabetes Care. ,vol. 14, pp. 1160- 1179 ,(1991) , 10.2337/DIACARE.14.12.1160