Mechanisms and functions of Hedgehog signalling across the metazoa
作者： Philip W. Ingham , Yoshiro Nakano , Claudia Seger
DOI: 10.1038/NRG2984
关键词: Signal transduction 、 Phylogenetics 、 Hedgehog 、 Drosophila melanogaster 、 Regulation of gene expression 、 Hedgehog signaling pathway 、 Genetics 、 Evolutionary biology 、 Biology 、 Genome 、 Whole genome sequencing
摘要: Hedgehog proteins constitute one of a small number families secreted signals that have central role in the development metazoans. Genetic analyses flies, fish and mice uncovered major components pathway transduces signals, recent genome sequence projects provided clues about its evolutionary origins. In this Review we provide an updated overview mechanisms functions signalling pathway, highlighting conserved divergent features as well some common themes deployment emerged from studies.
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