Developmental roles and clinical significance of hedgehog signaling.
作者： Andrew P McMahon , Philip W Ingham , Clifford J Tabin
DOI: 10.1016/S0070-2153(03)53002-2
关键词: Neuroscience 、 Cell signaling 、 Hedgehog signaling pathway 、 Multicellular organism 、 Biology 、 Cell biology 、 Clinical significance
摘要: Cell signaling plays a key role in the development of all multicellular organisms. Numerous studies have established importance Hedgehog wide variety regulatory functions during vertebrate and invertebrate Several reviews discussed components this pathway, their various interactions, some general principles that govern mechanisms. This review focuses on developing systems themselves, providing comprehensive survey each these. We also discuss increasing significance clinical setting.
sci-hub.se 参考文章(642)
W. Wuyts, K. de Boulle, F. Speleman, W. van Hul, J. Wauters, P. Bossuyt, N. van Roy, J. Hendrickx, P. J. Willems, T. van Agtmael, Identification and characterization of a novel member of the EXT gene family, EXTL2. European Journal of Human Genetics. ,vol. 5, pp. 382- 389 ,(1997) , 10.1007/BF03405947
Anthony E Oro, Matthew P Scott, Splitting Hairs: Dissecting Roles of Signaling Systems in Epidermal Development Cell. ,vol. 95, pp. 575- 578 ,(1998) , 10.1016/S0092-8674(00)81624-4
Michael T. Lewis, Hedgehog Signaling in Mouse Mammary Gland Development and Neoplasia Journal of Mammary Gland Biology and Neoplasia. ,vol. 6, pp. 53- 66 ,(2001) , 10.1023/A:1009516515338
Martin Bentz, Michael Baudis, Hartmut Döhner, Thomas F.E. Barth, Peter Möller, Stefan Joos, Claudius A. Werner, Peter Lichter, Lorenz H. Trümper, German Ott, High-level DNA amplifications are common genetic aberrations in B-cell neoplasms. American Journal of Pathology. ,vol. 151, pp. 335- 342 ,(1997) , 10.5167/UZH-18928
Roach E, Palmer C, Demyer W, Conneally Pm, Merritt Ad, Holoprosencephaly: birth data, benetic and demographic analyses of 30 families. Birth defects original article series. ,vol. 11, pp. 294- 313 ,(1975)
K. Peters, S. Werner, X. Liao, S. Wert, J. Whitsett, L. Williams, Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung. The EMBO Journal. ,vol. 13, pp. 3296- 3301 ,(1994) , 10.1002/J.1460-2075.1994.TB06631.X
J. Capdevila, I. Guerrero, Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings. The EMBO Journal. ,vol. 13, pp. 4459- 4468 ,(1994) , 10.1002/J.1460-2075.1994.TB06768.X
A Vaahtokari, I Thesleff, A M Partanen, Regulation of organogenesis. Common molecular mechanisms regulating the development of teeth and other organs. The International Journal of Developmental Biology. ,vol. 39, pp. 35- 50 ,(1995) , 10.1387/IJDB.7626420
Ying Litingtung, Chin Chiang, Specification of Ventral Neuron Types Is Mediated by an Antagonistic Interaction Between Shh and Gli3 Nature Neuroscience. ,vol. 3, pp. 979- 985 ,(2000) , 10.1038/79916
Mary Hynes, Weilan Ye, Kevin Wang, Donna Stone, Maximilien Murone, Frederic de Sauvage, Arnon Rosenthal, The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types Nature Neuroscience. ,vol. 3, pp. 41- 46 ,(2000) , 10.1038/71114