Moderate Dietary Salt Restriction Increases Vascular and Systemic Insulin Resistance

摘要: Our recent studies have indicated that severe salt restriction aggravates vascular insulin resistance in younger normotensive and hypertensive subjects. However, whether the extent of dietary commonly advocated adversely affects is unknown. To determine moderate might affect systemic sensitivity to insulin, we studied eight subjects after 1 week a normal sodium diet (235 mEq/day) (75 meq/day). Systemic as assessed by fasting plasma glucose-to-insulin ratio was aggravated (normal sodium: 1.2 +/- 0.1 mmol/mIU; low 0.6 0.1, P < .05). Salt significantly reduced maximal insulin-mediated vasodilation 51% 5% maximum nitroglycerin-mediated response; 28% 6%, .01). In contrast, no alterations nor phenylephrine-mediated vasoconstriction were noted. These demonstrate both resistance. This impairment vasodilating effect could be factor attenuating blood pressure lowering diet.