Short-term dietary sodium restriction increases serum lipids and insulin in salt-sensitive and salt-resistant normotensive adults.

摘要: Evidence suggests that dietary salt reduction similar to diuretic therapy may adversely affect lipid and glucose metabolism. We studied 147 non-obese normotensive subjects (60 females 87 males) aged 19-78 years who entered a single-blind crossover trial were randomly assigned low diet of 20 mmol or high 300 sodium per day, for 7 days each. Sodium restriction lowered mean arterial blood pressure (MAP) by 7.5 mmHg in 17% (salt-sensitive), had no hemodynamic effect 67% (salt-resistant) raised MAP 6 16% the (reverse reactors). With serum total- LDL-cholesterol as well insulin uric acid concentrations increased significantly all three groups. The largest increases total (10%) LDL- (12%) cholesterol occurred reverse reactors. Salt-sensitives significant higher lipoprotein(a) values than other two Salt-restriction on this parameter. Plasma renin activity, plasma aldosterone noradrenaline rose groups during diet, being observed Short-term adults has unfavourable effects metabolism, especially do not derive benefit. Further studies are necessary examine more moderate longer periods risk factor profile cardiovascular disease before can be regarded safe public health measure general population.