Sodium-sensitive hypertension is not associated with higher sympathetic nervous system activity in older hypertensive humans
作者： M. D. Brown , R. V. Hogikyan , D. R. Dengel , M. A. Supiano
DOI: 10.1016/S0895-7061(00)00256-9
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摘要: Abstract The majority of older hypertensive humans are sodium sensitive and they characterized by increased α-adrenergic responsiveness relative to their level sympathetic nervous system (SNS) activity. To test the hypothesis that heightened SNS activity and/or receptor during loading may play a role in sodium-dependent increase blood pressure sodium-sensitive hypertensives, we used compartmental analysis [3H]norepinephrine (NE) kinetics determine release rate NE into an extravascular compartment (NE2) as index systemic determined forearm flow responses graded intrabrachial artery angiotensin II (ANG II) infusions platelet membrane α2-receptor properties 24 (age 64 ± 7 years) subjects. Subjects were studied at end 1 week low (20 mmol/day)- again high (200 mmol/day)-sodium diet. categorized (SS) if had ≥ 5 mm Hg mean arterial (MABP) with dietary (n = 16), or sodium-resistant (SR) MABP
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