Water in hydroxyapatite nanopores: Possible implications for interstitial bone fluid flow.

摘要: The role of bone water in the activity this organ is essential structuring apatite crystals, providing pathways for nutrients and waste involved metabolism cells participating remodelling mechanotransduction. It commonly accepted that presents three levels porosity, namely vasculature, lacuno-canalicular system voids collagen-apatite matrix. Due to observation bound state at latter level, interstitial nanoscopic flow may exist within these pores classically neglected. aim paper investigate possibility obtain a fluid nanoscale. That why molecular dynamics based analysis water-hydroxyapatite proposed analyze effect confinement on transport properties. main result here free can be observed inside hydroxyapatite few nanometers. This would have strong implications multiscale treatment poromechanical behaviour tissue. In particular, mechanical properties matrix highly controlled by diffusion classical idea osteocytic only regulated discussed again.