Three-Scale Multiphysics Modeling of Transport Phenomena within Cortical Bone

摘要: Bone tissue can adapt its properties and geometry to physical environment. This ability is a key point in the osteointegration of bone implants since it controls remodeling in vicinity treated site. Since interstitial fluid ionic transport taking place compartments plays major role mechanotransduction remodeling, this theoretical study presents three-scale model multiphysical phenomena within vasculature porosity lacunocanalicular network cortical bone. These two levels exchange mass ions through permeable outer wall Haversian-Volkmann canals. Thus, coupled equations electrochemohydraulic are derived from nanoscale canaliculi toward tissue, considering intermediate scale intraosteonal tissue. In particular, Onsager reciprocity relations that govern are checked.