Significant variation in presentation of pulmonary tuberculosis across a high resolution of CD4 strata.

摘要: Approximately one third of the 33 million persons living with human immunodeficiency virus (PLHIV) worldwide are infected Mycobacterium tuberculosis.1 Of estimated 700 000 HIV-infected people active tuberculosis (TB), 85% live in sub-Saharan Africa, and TB is leading cause death among PLHIV Africa.2–4 at higher risk developing dying from compared to non-HIV-infected people.5,6 Shortening time pulmonary (PTB) diagnosis treatment initiation an important step reducing TB-associated mortality transmission. One major challenge diagnosing PTB alteration presentation due HIV infection. The problem exacerbated resource-limited settings without routine access mycobacterial culture. Alteration clinical radiographic has long been recognized.7,8 Multiple studies have demonstrated variation by infection status or CD4 cell count cut-offs.9–12 However, previous generally dichotomized (e.g., above below 200 cells/µl) describe level immune suppression, simply chest X-ray (CXR) findings patients. In this study, we evaluated across a large range strata cohort co-infected cases Kampala, Uganda, better understand relationship between PTB.