Preoperative serum cholesterol is an independent prognostic factor for patients with renal cell carcinoma (RCC)

摘要: Objective To assess the prognostic role of preoperative serum cholesterol in patients with renal cell carcinoma (RCC), as increasing evidence suggests that alterations lipid profile are associated development, progression and prognosis various cancers. Patients Methods We analysed 867 patients, who underwent radical or partial nephrectomy for RCC between 2002 2012. Preoperative total levels were determined using colorimetric analysis (CHOD-PAP method). The association cancer-specific survival (CSS) was assessed Cox models. Discrimination quantified C-index. median follow-up 52 months. Results The (interquartile range) 195 (166–232) mg/dL. Decreasing more advanced T, N M stages (P < 0.001), higher grades = 0.001) presence tumour necrosis 0.002). Continuously coded CSS both univariable (hazard ratio [HR] 0.87, P multivariable analyses (HR 0.93, 0.001). discrimination a base model increased significantly from 88.3% to 89.2% following inclusion 0.006). In clinically localised disease (T1–3N0/+M0), remained 0.90, 0.002) 74.6% 76.9% 0.002). Conclusions Preoperative is an independent factor RCC, lower being worse survival. Its use increases established factors. As broadly available routine marker, its may provide meaningful adjunct clinical practice. biological rationale underlying this remains be clarified.