Comparison of the prognostic value of pretreatment measurements of systemic inflammatory response in patients undergoing curative resection of clear cell renal cell carcinoma

摘要: Pretreatment measurements of systemic inflammatory response, including the Glasgow prognostic score (GPS), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte (MLR), platelet-to-lymphocyte (PLR) and nutritional index (PNI) have been recognized as factors in clear cell renal carcinoma (CCRCC), but there is at present no study that compared these markers. We evaluated pretreatment GPS, NLR, MLR, PLR PNI 430 patients, who underwent surgery for clinically localized CCRCC (pT1-3N0M0). Associations with disease-free survival were assessed Cox models. Discrimination was measured C-index, a decision curve analysis used to evaluate clinical net benefit. On multivariable analyses, all measures response significant factors. The increase discrimination stage, size, grade necrosis (SSIGN) alone 5.8 % 1.1–1.4 % 2.9–3.4 % 2.0–3.3 % 1.4–3.0 % PNI. simultaneous candidate measures, final model contained SSIGN (HR 1.40, P < 0.001), GPS 2.32, P < 0.001) MLR 5.78, P = 0.003) variables. Adding both increased by 6.2 % improved In patients CCRCC, appear be most relevant response. They may an adjunct patient counseling, tailoring management trial design.