Applicator and electrode design for in vivo DNA delivery by electroporation.

摘要: As in vivo electroporation advances from the preclinical phase to clinical studies and eventually routine medical practice, design of devices becomes increasingly important. Achieving safety efficacy levels that meet regulatory requirements, as well user patient friendliness, are major considerations. In addition, will have be economical manufacture. This chapter focus on applicators electrodes, pieces hardware direct contact with patient, thus key elements responsible for procedure. The two foreseeable applications technology DNA field gene therapy vaccination. Design requirements differ considerably these diseases treated or prevented. addition trend device differentiation, there is also a build capable performing both step delivering target tissue subsequent electroporation. presents electrical biological principles underlying applicator electrode design, gives an overview existing devices, discusses their advantages disadvantages. outlines considerations, including pathways, points out potential future developments.