DNA vaccines and intradermal vaccination by DNA tattooing.

摘要: Over the past two decades, DNA vaccination has been developed as a method for induction of immune responses. However, in spite high expectations based on their efficacy preclinical models, immunogenicity first generation vaccines clinical trials was shown to be poor, and no have yet licensed human use. In recent years significant progress made development second vaccine delivery methods. Here we review key characteristics compared other platforms, insights into prerequisites responses by will discussed. We illustrate with description tattooing novel method. This technique great promise both small animal model non-human primates is currently under evaluation.