Transition-metal-free direct perfluoroalkylation of quinoline amides at C5 position through radical cross-coupling under mild conditions
作者： Jun Xu , Li Qiao , Beibei Ying , Xiaolei Zhu , Chao Shen
DOI: 10.1039/C6QO00655H
关键词: Chemistry 、 Catalysis 、 Photochemistry 、 Coupling 、 Transition metal 、 Quinoline 、 Lower energy
摘要: A simple and efficient method is established for the synthesis of perfluoroalkylated quinolines in absence any transition metal catalysts. The eco-friendly reaction reveals lower energy time consumption. Desired products are isolated good to excellent yields. number control experiments carried out illustrate that a radical cross-coupling process plays vital role perfluoroalkylation.
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