4-N,N-Dimethylaminosulfonyl-7-N-(2-aminoethyl)amino-benzofurazan as a new precolumn fluorescence derivatization reagent for carboxylic acids (fatty acids and drugs containing a carboxyl moiety) in liquid chromatography
作者： P. Prados , T. Fukushima , T. Santa , H. Homma , M. Tsunoda
DOI: 10.1016/S0003-2670(97)00020-2
关键词: Derivatization 、 Fluorescence spectrometry 、 Triphenylphosphine 、 Amine gas treating 、 Reagent 、 Carboxylic acid 、 Organic chemistry 、 Moiety 、 Chromatography 、 Fatty acid 、 Chemistry
摘要: Abstract A new fluorescent reagent for carboxylic acids, 4-N,N-dimethylaminosulfonyl-7-N-(2-aminoethyl)amino-2,l,3-benzoxadiazole (DBD-ED) was synthesized from 4-N,N-dimethylaminosulfonyl-7-chloro-2,1,3-benzoxadiazole (DBD-Cl) and 1,2-diaminoethane. DBD-Cl is also a compound described in this work the first time. The applicability of DBD-ED as precolumn derivatization liquid chromatography (LC) examined. reacted with saturated fatty acids non-steroidal anti-inflammatory drugs (NSAIDs) presence triphenylphosphine 2,2′-dipyridyl disulfide at room temperature 30 min NSAIDs 1 h to give products. reaction solutions were subjected LC derivatized products detected spectrofluorimetrically 560 nm excitation 450 nm. detection limits fmol range
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