Analysis of MUTYH alternative transcript expression, promoter function, and the effect of human genetic variants.
作者： Nicole Köger , Angela Brieger , Inga M. Hinrichsen , Stefan Zeuzem , Guido Plotz
DOI: 10.1002/HUMU.23709
关键词: MUTYH 、 Gene 、 Transcription factor 、 Biology 、 Transcription (biology) 、 Minigene 、 RNA splicing 、 Promoter 、 Genetics 、 CAAT box
摘要: … We identified highly conserved promoter areas and inactivated them in the minigene, and … The findings allowed to attribute regulatory roles to three conserved motifs in the promoter: an …
sci-hub.se 
researchgate.net 参考文章(46)
Peter A. Jones, Vincent L. Wilson, Richard L. Momparler, Inhibition of DNA methylation in L1210 leukemic cells by 5-aza-2'-deoxycytidine as a possible mechanism of chemotherapeutic action. Cancer Research. ,vol. 43, pp. 3493- 3496 ,(1983)
Françoise Praz, Sandrine Jacob, Mélanie Aguado, David Fallik, The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells. Cancer Research. ,vol. 61, pp. 6555- 6562 ,(2001)
Malcolm G. Dunlop, Susan M. Farrington, MUTYH-associated polyposis and colorectal cancer. Surgical Oncology Clinics of North America. ,vol. 18, pp. 599- 610 ,(2009) , 10.1016/J.SOC.2009.08.003
Hong Tao, Kazuya Shinmura, Masaya Suzuki, Suminori Kono, Ryuichi Mibu, Masao Tanaka, Yoshihiro Kakeji, Yoshihiko Maehara, Takeshi Okamura, Kouji Ikejiri, Kitaroh Futami, Youichi Yasunami, Takafumi Maekawa, Kenji Takenaka, Hitoshi Ichimiya, Nobutoshi Imaizumi, Haruhiko Sugimura, Association between genetic polymorphisms of the base excision repair gene MUTYH and increased colorectal cancer risk in a Japanese population Cancer Science. ,vol. 99, pp. 355- 360 ,(2008) , 10.1111/J.1349-7006.2007.00694.X
Joerg Trojan, Stefan Zeuzem, Ann Randolph, Christine Hemmerle, Angela Brieger, Jochen Raedle, Guido Plotz, Josef Jiricny, Giancarlo Marra, Functional analysis of hMLH1 variants and HNPCC-related mutations using a human expression system. Gastroenterology. ,vol. 122, pp. 211- 219 ,(2002) , 10.1053/GAST.2002.30296
Young-Kyo Seo, Hansook Kim Chong, Aniello M Infante, Seung-Soon Im, Xiaohui Xie, Timothy F Osborne, Genome-wide analysis of SREBP-1 binding in mouse liver chromatin reveals a preference for promoter proximal binding to a new motif Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 13765- 13769 ,(2009) , 10.1073/PNAS.0904246106
Dirk Petersohn, Gerald Thiel, Role of Zinc-Finger Proteins Sp1 and Zif268/egr-1 in Transcriptional Regulation of the Human Synaptobrevin II Gene FEBS Journal. ,vol. 239, pp. 827- 834 ,(1996) , 10.1111/J.1432-1033.1996.0827U.X
Filomena Mazzei, Alessandra Viel, Margherita Bignami, Role of MUTYH in human cancer. Mutation Research. ,vol. 743, pp. 33- 43 ,(2013) , 10.1016/J.MRFMMM.2013.03.003
Bor-Jang Hwang, Gouli Shi, A.-Lien Lu, Mammalian MutY homolog (MYH or MUTYH) protects cells from oxidative DNA damage. DNA Repair. ,vol. 13, pp. 10- 21 ,(2014) , 10.1016/J.DNAREP.2013.10.011
David W. Meek, Tumour suppression by p53: a role for the DNA damage response? Nature Reviews Cancer. ,vol. 9, pp. 714- 723 ,(2009) , 10.1038/NRC2716