Effects of daily environmental enrichment on memory deficits and brain injury following neonatal hypoxia-ischemia in the rat.
作者： Lenir Orlandi Pereira , Nice Sarmento Arteni , Ruth Chamorro Petersen , Anderson Padilha da Rocha , Matilde Achaval
DOI: 10.1016/J.NLM.2006.07.003
关键词: Morris water navigation task 、 Water maze 、 Stimulation 、 Working memory 、 Neuroscience 、 Memory disorder 、 Medicine 、 Cerebral cortex 、 Environmental enrichment 、 Ischemia
摘要: Abstract Environmental enrichment (EE) results in improved learning and spatial memory, as well attenuates morphological changes resulting from cerebral ischemia adult animals. This study examined the effects of daily EE on memory deficits water maze damage, assessed hippocampus cortex, caused by neonatal hypoxia-ischemia. Male Wistar rats 7th postnatal day were submitted to Levine-Rice model hypoxia-ischemia (HI), comprising permanent occlusion right common carotid artery a period hypoxia (90 min, 8%O 2 –92%N ). Starting two weeks after HI event, animals stimulated enriched environment (1 h/day for 9 weeks); subsequent stimulation, performance was assessed. resulted reference working impairments that completely reversed EE. Following behavioral study, killed hippocampal volume cortical area estimated. There significant reduction both area, ipsilateral arterial occlusion, animals; environmental stimulation had no effect these measurements. Presented data indicate recovers without affecting tissue atrophy either or cortex.
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