Brain serotonin reuptake did not change during one year in overtrained athletes.

摘要: Brain 5-HT neurotransmission has been described to be down-regulated in depressed people, and also suspected changed overtraining state, the consequence of long-term physical overloading stress athletes. We studied brain serotonin (5-HT) transporter binding i.e., reuptake with specific radioligand (123-I-labelled 2beta-carbomethoxy-3beta[4-iodopenyl]-nortropane, Nor-beta-CIT), single photon emission tomography (SPET) severely overtrained athletes their controls at baseline after a one-year recovery period. Twelve (6 women 6 men, mean age 27 yrs, range 16 - 39 yrs) 11 healthy women, 5 26 20 were examined. Overtrained 1) had suffered from an unexplained decrement performance fatigue for several weeks many months continued have same symptoms even time months, 2) examined otherwise healthy, 3) suitable training history overtraining. Nor-beta-CIT SPET was acquired min, 3, 6, 24 h injection radioligand. ml/ml midbrain (raphe nuclei) calculated as (midbrain cerebellum)/cerebellum. According two-way analysis variance, no changes inside groups or group differences found. Male significantly higher than female (p = 0.034). The moderately depressed, while scores standardized Hamilton Montgomery-Asberg Depression Rating Scales +/- 2 (mean SEM, 8 29) 17 (7 28), respectively. In CA, 1 (range 18) (1 19), did not correlate depression either whole OA. finding present study does support idea this case midbrain, regulating area neurotransmission. Furthermore, may its own variant having correlation midbrain. Sex effect on chronic response level athletes, which confusing factor studies, taken into consideration future.