Combretastatins: more than just vascular targeting agents?

作者: Lisa M. Greene , Mary J. Meegan , Daniela M. Zisterer

DOI: 10.1124/JPET.115.226225

关键词: Programmed cell deathTubulin ModulatorsAutophagyPharmacologyTubulinLeukemiaCell cycle checkpointBiologyProdrugMitotic catastrophe

摘要: Several prodrugs of the naturally occurring combretastatins have undergone extensive clinical evaluation as vascular targeting agents (VTAs). Their increased selectivity toward …

参考文章(200)
M. R. Horsman, R. Murata, T. Breidahl, F. U. Nielsen, R. J. Maxwell, H. Stødkiled-Jørgensen, J. Overgaard., Combretastatins Novel Vascular targeting Drugs for Improving Anticancer therapy Springer, Boston, MA. pp. 311- 323 ,(2000) , 10.1007/978-1-4615-4221-6_26
Stephen L. Gwaltney, Hovis M. Imade, Kenneth J. Barr, Qun Li, Laura Gehrke, R.Bruce Credo, Robert B. Warner, Jang Yun Lee, Peter Kovar, Jieyi Wang, Michael A. Nukkala, Nicolette A. Zielinski, David Frost, Shi-Chung Ng, Hing L. Sham, Novel sulfonate analogues of combretastatin A-4 Bioorganic & Medicinal Chemistry Letters. ,vol. 11, pp. 871- 874 ,(2001) , 10.1016/S0960-894X(01)00098-1
George Pettit, D. J. Swaine, P. M. Loadman, K. Grosios, M. C. Bibby, Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma. Anticancer Research. ,vol. 20, pp. 229- 233 ,(2000)
Cheng‐Huang Shen, Jia‐Jen Shee, Jin‐Yi Wu, Yi‐Wen Lin, Jiann‐Der Wu, Yi‐Wen Liu, None, Combretastatin A-4 inhibits cell growth and metastasis in bladder cancer cells and retards tumour growth in a murine orthotopic bladder tumour model. British Journal of Pharmacology. ,vol. 160, pp. 2008- 2027 ,(2010) , 10.1111/J.1476-5381.2010.00861.X
Vivien E. Prise, George R. Pettit, Graham G. Dark, Sally A. Hill, Dai J. Chaplin, Gillian M. Tozer, Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature Cancer Research. ,vol. 57, pp. 1829- 1834 ,(1997)
Gina Marcela Méndez-Callejas, Stefano Leone, Caterina Tanzarella, Antonio Antoccia, Combretastatin A-4 induces p53 mitochondrial-relocalisation independent-apoptosis in non-small lung cancer cells. Cell Biology International. ,vol. 38, pp. 296- 308 ,(2014) , 10.1002/CBIN.10199
Xuexin He, Su Li, He Huang, Zhiming Li, Likun Chen, Sheng Ye, Jiajia Huang, Jing Zhan, Tongyu Lin, A pharmacokinetic and safety study of single dose intravenous combretastatin A4 phosphate in Chinese patients with refractory solid tumours. British Journal of Clinical Pharmacology. ,vol. 71, pp. 860- 870 ,(2011) , 10.1111/J.1365-2125.2011.03928.X
GILLIAN M. TOZER, CHRYSO KANTHOU, CHARLES S. PARKINS, SALLY A. HILL, The biology of the combretastatins as tumour vascular targeting agents International Journal of Experimental Pathology. ,vol. 83, pp. 21- 38 ,(2002) , 10.1046/J.1365-2613.2002.00211.X
Sanjeev Kumar, Mahdi, Shah, Garg, Bryant, Munkarah, Clinical trials and progress with paclitaxel in ovarian cancer International Journal of Women's Health. ,vol. 2, pp. 411- 427 ,(2010) , 10.2147/IJWH.S7012
Stanley E. Read, Maurice Levy, Michael Spino, Colchicine: A State‐of‐the‐Art Review Pharmacotherapy. ,vol. 11, pp. 196- 211 ,(1991) , 10.1002/J.1875-9114.1991.TB02629.X