Combretastatins Novel Vascular targeting Drugs for Improving Anticancer therapy
作者： M. R. Horsman , R. Murata , T. Breidahl , F. U. Nielsen , R. J. Maxwell
DOI: 10.1007/978-1-4615-4221-6_26
关键词: Pharmacology 、 Inhibitory effect 、 Combretastatin 、 Hyperthermia 、 Necrosis 、 Disodium phosphate 、 Medicine 、 Tumour perfusion 、 Oxygenation 、 Drug
摘要: Combretastatins are a new class of compounds that appear to have antitumour activity as result specifically targeting the vasculature tumours. The aim this study was investigate potential combretastatin A-4 disodium phosphate (CA4DP) induce vascular effects in C3H mouse mammary carcinoma, and see if anti-tumour response could be improved by combining drug with conventional anticancer therapies. It found CA4DP (250 mg/kg) significantly decreased tumour perfusion within 30 minutes after injection maintained decrease for several hours, although there return normal 24 hours. Similar changes were seen tumours bioenergetic oxygenation status. also increased necrosis had small inhibitory effect on growth. able enhance radiation hyperthermia, when given at same time or respectively. Giving 1 hour cisplatin only resulted no greater than additive. These results confirm anti-vascular demonstrate its therapy.
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sci-hub.st 参考文章(31)
M. R. Horsman, L. E. Sampson, D. J. Chaplin, J. Overgaard, The in vivo interaction between flavone acetic acid and hyperthermia. International Journal of Hyperthermia. ,vol. 12, pp. 779- 789 ,(1996) , 10.3109/02656739609027684
Judah Folkman, What is the evidence that tumors are angiogenesis dependent Journal of the National Cancer Institute. ,vol. 82, pp. 4- 7 ,(1990) , 10.1093/JNCI/82.1.4
Sally A. Hill, Juliana Denekamp, The effect of vascular occlusion on the thermal sensitization of a mouse tumour British Journal of Radiology. ,vol. 51, pp. 997- 1002 ,(1978) , 10.1259/0007-1285-51-612-997
Michael R. Horsman, Kent L. Christensen, And Jens Overgaard, Hydralazine-induced enhancement of hyperthermic damage in a C3H mammary carcinoma in vivo. International Journal of Hyperthermia. ,vol. 5, pp. 123- 136 ,(1989) , 10.3109/02656738909140442
George Pettit, S. A. Hill, D. J. Chaplin, Anti-vascular approaches to solid tumour therapy: evaluation of combretastatin A4 phosphate. Anticancer Research. ,vol. 19, pp. 189- 195 ,(1999)
C. Anne Wallen, Thomas V. Colby, J. Robert Stewart, Cell Kill and Tumor Control after Heat Treatment with and without Vascular Occlusion in RIF-1 Tumors Radiation Research. ,vol. 106, pp. 215- 223 ,(1986) , 10.2307/3576795
Colchicine in the Experimental Chemotherapy of Cancer Journal of the National Cancer Institute. ,vol. 6, pp. 89- 101 ,(1945) , 10.1093/JNCI/6.2.89
Leo A. Sapirstein, Regional blood flow by fractional distribution of indicators. American Journal of Physiology. ,vol. 193, pp. 161- 168 ,(1958) , 10.1152/AJPLEGACY.1958.193.1.161
Peter Vaupel, Paul Okunieff, Joachim Kalmus, Dose-dependent Effects of Hydralazine on Microcirculatory Function and Hyperthermic Response of Murine FSall Tumors Cancer Research. ,vol. 50, pp. 15- 19 ,(1990)
Vivien E. Prise, George R. Pettit, Graham G. Dark, Sally A. Hill, Dai J. Chaplin, Gillian M. Tozer, Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature Cancer Research. ,vol. 57, pp. 1829- 1834 ,(1997)