Genotyping of CYP2C9 and VKORC1 in the Arabic Population of Al-Ahsa, Saudi Arabia

摘要: Polymorphisms in the genes encoding CYP2C9 enzyme and VKORC1 reductase significantly influence dose variability of coumarinic oral anticoagulants (COAs). Substantial inter- intraethnic exists frequencies CYP2C9∗2 ∗3 –1639A alleles. However, prevalence genetic variants is less characterized Arab populations. A total 131 healthy adult subjects from Al-Ahsa region Saudi Arabia were genotyped for –1639G>A polymorphisms by PCR-RFLP method. The alleles 13.3%, 2.3%, 42.4%, respectively, with no carrying 2 defective CYP2C9∗3 lower than those reported different Arabian None –1639AA genotype carriers CYP2C9∗1/∗3 genotypes that lead to sensitivity COAs therapy. low frequency allele combined absence suggests that, this specific population, pharmacogenetic dosing may mostly rely upon genotyping.