Validation of a new fluorogenic real-time PCR assay for detection of CYP2C9 allelic variants and CYP2C9 allelic distribution in a German population.

作者: Maria Burian , Sabine Grösch , Irmgard Tegeder , Gerd Geisslinger

DOI: 10.1046/J.1365-2125.2002.01693.X

关键词:

摘要: Aims The aim was to develop a fast detection method for the polymorphic alleles related impaired CYP2C9-mediated metabolism.

参考文章(11)
Sükrü Aynacioglu, Jürgen Brockmöller, Steffen Bauer, Christoph Sachse, Pinar Güzelbey, Zuhal Öngen, Muradiye Nacak, Ivar Roots, Frequency of cytochrome P450 CYP2C9 variants in a Turkish population and functional relevance for phenytoin British Journal of Clinical Pharmacology. ,vol. 48, pp. 409- 415 ,(1999) , 10.1046/J.1365-2125.1999.00012.X
Maria Gabriella Scordo, Eleni Aklillu, Umit Yasar, Marja-Liisa Dahl, Edoardo Spina, Magnus Ingelman-Sundberg, Genetic polymorphism of cytochrome P450 2C9 in a Caucasian and a black African population. British Journal of Clinical Pharmacology. ,vol. 52, pp. 447- 450 ,(2001) , 10.1046/J.0306-5251.2001.01460.X
Young-Ran Yoon, Ji-Hong Shon, Moon-Kyung Kim, Young-Chai Lim, Hye-Rang Lee, Ji-Young Park, In-June Cha, Jae-Gook Shin, Frequency of cytochrome P450 2C9 mutant alleles in a Korean population. British Journal of Clinical Pharmacology. ,vol. 51, pp. 277- 280 ,(2001) , 10.1046/J.1365-2125.2001.00340.X
Michael J. Stubbins, Lorna W. Harries, Gillian Smith, Michael H. Tarbit, C Roland Wolf, Genetic analysis of the human cytochrome P450 CYP2C9 locus. Pharmacogenetics. ,vol. 6, pp. 429- 439 ,(1996) , 10.1097/00008571-199610000-00007
Allan E. Rettie, Larry C. Wienkers, Frank J. Gonzalez, William F. Trager, Kenneth R. Korzekwa, Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9. Pharmacogenetics. ,vol. 4, pp. 39- 42 ,(1994) , 10.1097/00008571-199402000-00005
C Ramana Bhasker, John O. Miners, Sally Coulter, Donald J. Birkett, Allelic and functional variability of cytochrome P4502C9. Pharmacogenetics. ,vol. 7, pp. 51- 58 ,(1997) , 10.1097/00008571-199702000-00007
Theresa H. Sullivan-Klose, Burhan I. Ghanayem, Douglas A. Bell, Zhi-Yi Zhang, Laurence S. Kaminsky, Gillian M. Shenfleld, John O. Miners, Donald J. Birkett, Joyce A. Goldstein, The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism. Pharmacogenetics. ,vol. 6, pp. 341- 349 ,(1996) , 10.1097/00008571-199608000-00007
Jan van der Weide, Linda S. W. Steijns, Marga J. M. van Weelden, Keimpe de Haan, The effect of genetic polymorphism of cytochrome P450 CYP2C9 on phenytoin dose requirement. Pharmacogenetics. ,vol. 11, pp. 287- 291 ,(2001) , 10.1097/00008571-200106000-00002
Hideaki Ninomiya, Kohsuke Mamiya, Shin-ichiro Matsuo, Ichiro Ieiri, Shun Higuchi, Nobutada Tashiro, Genetic polymorphism of the CYP2C subfamily and excessive serum phenytoin concentration with central nervous system intoxication. Therapeutic Drug Monitoring. ,vol. 22, pp. 230- 232 ,(2000) , 10.1097/00007691-200004000-00016
Daniel J. Steward, Robert L. Haining, Kirk R. Henne, George Davis, Thomas H. Rushmore, William F. Trager, Allan E. Rettie, Genetic association between sensitivity to warfarin and expression of CYP2C9*3 Pharmacogenetics. ,vol. 7, pp. 361- 367 ,(1997) , 10.1097/00008571-199710000-00004