Hematopoietic growth factors released by marrow stromal cells from patients with aplastic anemia
作者： S Kojima , T Matsuyama , Y Kodera
DOI: 10.1182/BLOOD.V79.9.2256.BLOODJOURNAL7992256
关键词: Medicine 、 Granulocyte macrophage colony-stimulating factor 、 Aplastic anemia 、 Stromal cell 、 Granulocyte 、 Haematopoiesis 、 Cytokine 、 Endocrinology 、 Granulocyte colony-stimulating factor 、 Internal medicine 、 Growth factor
摘要: We studied the production of granulocyte colony-stimulating factor (G- CSF), granulocyte-macrophage (GM-CSF), and interleukin-6 (IL-6) by stromal cells from 33 patients with aplastic anemia (AA). Complete, confluent layers were produced 29 samples using long-term bone marrow culture (LTBMC) system. The concentration G-CSF, GM-CSF, IL-6 in media or without interleukin-1 (IL-1) stimulation was determined an enzyme- linked immunoadsorbent assay (ELISA). spontaneous G- CSF, did not differ significantly between normal controls AA. ability to release three hematopoietic growth factors response IL-1 either elevated all but one patient. also change before after antilymphocyte globulin (ALG) therapy 16 There no correlation these cytokines ALG. In contrast previous studies that showed a defect AA, results indicated
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