Interleukin 1 stimulates fibroblasts to synthesize granulocyte-macrophage and granulocyte colony-stimulating factors. Mechanism for the hematopoietic response to inflammation.
作者： N Lin , J W Adamson , K Kaushansky
DOI: 10.1172/JCI113316
关键词: Granulocyte 、 In vitro 、 In vivo 、 Immunology 、 Biology 、 Colony-stimulating factor 、 Interleukin 、 Haematopoiesis 、 Inflammation 、 Bone marrow
摘要: IL-1 is a family of polypeptides which play critical role in the inflammatory response. Characteristics this response include an enhanced release bone marrow neutrophils, activation circulating and tissue-phase phagocytes, production neutrophils monocytes. We have sought to understand hematopoietic acute chronic states on cellular molecular level. Colony-stimulating factors (CSFs) are glycoproteins involved monocytes vitro vivo. found that quiescent dermal fibroblasts constitutively granulocyte-macrophage CSF (GM-CSF), granulocyte (G-CSF), macrophage culture, picomolar concentrations mediator stimulate by at least fivefold transcription GM-CSF G-CSF. These findings establish inflammation through stimulation
sci-hub.st 参考文章(40)
A. Ullrich, C.H. Berman, T.J. Dull, A. Gray, J.M. Lee, Isolation of the human insulin-like growth factor I gene using a single synthetic DNA probe. The EMBO Journal. ,vol. 3, pp. 361- 364 ,(1984) , 10.1002/J.1460-2075.1984.TB01812.X
D Rennick, G Yang, L Gemmell, F Lee, Control of Hemopoiesis by a Bone Marrow Stromal Cell Clone: Lipopolysaccharide- and Interleukin-1--Inducible Production of Colony-Stimulating Factors Blood. ,vol. 69, pp. 682- 691 ,(1987) , 10.1182/BLOOD.V69.2.682.682
K Kaushansky, J M Harlan, V C Broudy, J W Adamson, Interleukin 1 stimulates human endothelial cells to produce granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor. Journal of Immunology. ,vol. 139, pp. 464- 468 ,(1987)
D Metcalf, The molecular biology and functions of the granulocyte-macrophage colony-stimulating factors. Blood. ,vol. 67, pp. 257- 267 ,(1986) , 10.1182/BLOOD.V67.2.257.257
D T Umetsu, H H Jabara, R S Geha, D Katzen, Antigen presentation by human dermal fibroblasts: activation of resting T lymphocytes. Journal of Immunology. ,vol. 136, pp. 440- 445 ,(1986)
Norman Rave, Radomir Crkvenjakov, Helga Boedtker, Identification of procollagen mRNAs transferred to diazobenzyloxymethyl paper from formaldehyde agarose gels Nucleic Acids Research. ,vol. 6, pp. 3559- 3568 ,(1979) , 10.1093/NAR/6.11.3559
K. Kaushansky, P. J. O'Hara, K. Berkner, G. M. Segal, F. S. Hagen, J. W. Adamson, Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 3101- 3105 ,(1986) , 10.1073/PNAS.83.10.3101
Kenneth Kaushansky, Patrick J. O'Hara, Charles E. Hart, John W. Forstrom, Frederick S. Hagen, Role of carbohydrate in the function of human granulocyte−macrophage colony-stimulating factor Biochemistry. ,vol. 26, pp. 4861- 4867 ,(1987) , 10.1021/BI00389A038
G C Bagby, V D Rigas, R M Bennett, A A Vandenbark, H S Garewal, Interaction of lactoferrin, monocytes, and T lymphocyte subsets in the regulation of steady-state granulopoiesis in vitro. Journal of Clinical Investigation. ,vol. 68, pp. 56- 63 ,(1981) , 10.1172/JCI110254
Carl J. March, Bruce Mosley, Alf Larsen, Douglas Pat Cerretti, Gary Braedt, Virginia Price, Steven Gillis, Christopher S. Henney, Shirley R. Kronheim, Kenneth Grabstein, Paul J. Conlon, Thomas P. Hopp, David Cosman, Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs Nature. ,vol. 315, pp. 641- 647 ,(1985) , 10.1038/315641A0