Recombinant hematopoietic growth factors in bone marrow transplantation.
作者： John Nemunaitis
DOI: 10.1007/978-1-4615-2013-9_10
关键词:
摘要: Hematopoietic growth factors are naturally occurring glycoproteins that stimulate the proliferation of hematopoietic cells [1–3]. Initial discovery was based on proliferative activity identified by in vitro assay systems. Erythropoietin (EPO) stimulates erythrocyte maturation, granulocyte-colony-stimulating factor (G-CSF) neutrophil proliferation, and granulocyte-macrophage-colony-stimulating (GM-CSF) neutrophil, monocyte, macrophage proliferation. These three recombinant cytokines have been approved Food Drug Administration (FDA) for clinical use being evaluated patients undergoing bone marrow or peripheral blood stem cell transplantation.
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