Ring closing metathesis in organic synthesis: Evolution of a high speed, solid phase method for the preparation of β-turn mimetics
作者： Anthony D Piscopio , John F Miller , Kevin Koch
DOI: 10.1016/S0040-4020(99)00300-2
关键词: Cleavage (embryo) 、 Sequence (biology) 、 Chemistry 、 Phase method 、 Lactam 、 Tandem 、 Ring-closing metathesis 、 Combinatorial chemistry 、 Organic chemistry 、 Phase (matter) 、 Organic synthesis
摘要: Abstract Complimentary solid phase syntheses of the Freidinger lactam class β-turn mimetics have been developed using ring closing metathesis as both key carbon-carbon bond forming step and cyclative cleavage mechanism. Solid variants Fukuyama-Mitsunobu process were utilized part a rapid three-step sequence to construct immobilized precursors. An alternative is offered which utilizes an Ugi/ring reaction tandem deliver desired compounds in two synthetic operations.
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