Interleukin-1 enhances survival of lethally irradiated mice treated with allogeneic bone marrow cells

摘要: Interleukin-1 (IL-1) enhanced the capacity of allogeneic bone marrow (BM) cells to promote survival mice given doses radiation (1,200 1,350 cGy) that are significantly higher than those generally used for BM ablation (850 950 cGy). Three five times greater numbers lethally irradiated C57B1/6 (H-2b) 10(7) T-cell-depleted Balb/c (H-2d) survived over 6 weeks if also treated with a single intraperitoneal (IP) dose 10 micrograms IL-1 20 hours before or from 1 3 after radiation. The spleens these were reconstituted predominantly, but not exclusively, donor (54% 91%). Histologic examination epidermal and gastrointestinal tissues surviving more did reveal any evidence graft-versus-host (GVH) disease; however, since 10% 43% died between days 30 46, possibility GVH syndrome in cannot be excluded. spleen transplants IL-1, which consisted equal 85% cells, able generate specific T-cell cytotoxic killing unrelated unreactive target bearing either host major histocompatibility complex (MHC) class I antigens. Thus, long-term mixed chimeric survivors tolerant recipient alloantigens exhibited immunologic competence. These results show promotes hematopoietic such animals develop tolerance MHC Although there many unanswered questions, data suggest may prove clinically useful promoting engraftment.