The Immobilized Copper on Nickel Ferrite: A Magnetically Superior Nanocatalyst for Chemoselective and Knoevenagel Synthesis of Bisdimedones and 1,8-Dioxo-octahydroxanthenes under Solvent-Free Conditions.

摘要: AIM AND OBJECTIVE Nowadays, bisdimedones and 1,8-dioxo-octahydroxanthenes are considered as biologically active materials. Due to this, the synthesis of mentioned materials is subject more interest. Although most reported methods have their own merits, however, they generally require use expensive reagents, hazardous organic solvents, a tedious workup procedure reduced recyclability applied catalyst system. Overcoming above drawbacks, therefore, encouraged us investigate capability nanostructured NiFe2O4@Cu towards 1,8- dioxo-octahydroxanthenes under green reaction conditions. MATERIALS METHODS Nanoparticles were prepared via two-step including preparation NiFe2O4 by solid-state grinding Ni(OAc)2·4H2O Fe(NO3)3·9H2O in presence NaOH followed immobilization Cu(0) on surface nucleus hydrazine hydrate reduction Cu(NO3)2·3H2O. RESULTS After NiFe2O4@Cu, catalytic activity Cu-nanocatalyst Knoevenagel aromatic aldehydes with dimedone different conditions was investigated. The examinations showed that using molar equivalents (1 mmol) (2 0.15 g solvent-free chemoselectively afforded structurally bisdimedone products at 60°C 120°C. CONCLUSION In this study, magnetically, nanoparticles then characterized analyses. also studied condensation dimedone. All reactions carried out within 15-240 min afford 1,8-dioxo-octahydroxanthene high yields.