Association of single‐nucleotide polymorphism rs4236601 near caveolin 1 and 2 with primary open‐angle glaucoma: a meta‐analysis

摘要: Background To clarify the effects of a single-nucleotide polymorphism, rs4236601[A] near caveolin 1 and 2, on primary open-angle glaucoma (POAG) risk. Design Meta-analysis. Participants A total 5774 patients 40 598 controls from previously reported case–control studies were included. Methods A comprehensive literature search was performed for published up to April 2013. Summary odds ratios (ORs) 95% confidence intervals (CI) calculated, employing random- or fixed-effects models according between-study heterogeneity. Publication bias articles evaluated using funnel plots Egger's test. Main Outcome Measures OR POAG risk. Results Five eligible included in this meta-analysis. Overall, association between risk statistically significant (OR = 1.23, CI 1.12–1.34; P < 0.001). Stratified analyses showed that Caucasians (OR = 1.25, 1.18–1.33; P < 0.001) Asians (OR = 3.33, 1.56–7.08; P = 0.003) but not Africans. Increased risks found age- sex-matched (OR = 1.26, 1.14–1.40; P < 0.001), no unmatched studies. Conclusions This meta-analysis suggests is associated with increased Caucasian Asian populations. However, well-designed gene–environment interaction including more ethnic groups are required further investigations.