Immunologic injury of cultured cells infected with measles virus. I. role of IfG antibody and the alternative complement pathway.

摘要: In these studies, a number of human cell lines including epithelial, neural, glial, and lymphoid cells infected with several strains measles virus were found to be lysed upon incubation fresh sera from humans containing antibody virus. all instances, the cytolytic event was mediated by alternative complement (C) pathway without significant contribution classical pathway. contrast, isolated in conjunction selectively activate C Measles antibodies IgG class, but not IgA possessed potential against Human could directly No defect or cerebrospinal fluid patients subacute sclerosing panencephalitis, nor impaired patients. Sera newborn exhibited functional