Polymeric Nanoparticles of Brazilian Red Propolis Extract: Preparation, Characterization, Antioxidant and Leishmanicidal Activity
作者： Ticiano Gomes Do Nascimento , Priscilla Fonseca Da Silva , Lais Farias Azevedo , Louisianny Guerra Da Rocha , Isabel Cristina Celerino de Moraes Porto
DOI: 10.1186/S11671-016-1517-3
关键词: Formononetin 、 Dosage form 、 Isoliquiritigenin 、 Propolis 、 Chromatography 、 Biochanin A 、 Organic chemistry 、 Materials science 、 Chromatography detector 、 Pinobanksin 、 Liquiritigenin 、 General Materials Science 、 Condensed matter physics
摘要: The ever-increasing demand for natural products and biotechnology derived from bees ultra-modernization of various analytical devices has facilitated the rational planned development with a focus on human health to treat chronic neglected diseases. aim present study was prepare characterize polymeric nanoparticles loaded Brazilian red propolis extract evaluate cytotoxic activity “multiple-constituent in co-delivery system” antileishmanial therapies. were prepared combination poly-e-caprolactone pluronic using nanoprecipitation method characterized by different techniques, antioxidant leishmanicidal assay. aqueous medium presented particle size (200–280 nm) nanometric scale zeta analysis (−20 −26 mV) revealed stability without aggregation phenomenon during 1 month. After freeze-drying cryoprotectant (sodium starch glycolate), it possible observe particles smooth spherical shape apparent 200 400 nm. Attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) thermal encapsulation flavonoids into matrix. Ultra performance liquid chromatography coupled diode array detector (UPLC-DAD) identified liquiritigenin, pinobanksin, isoliquiritigenin, formononetin biochanin A ethanolic (EEP) (NRPE). efficiency determinate, median values (75.0 %) calculated UPLC-DAD. 2,2-Diphenyl-1-picryhydrazyl showed EEP nanoparticles. Compared negative control, NRPE exhibited an IC50 value ≅38.0 μg/mL 31.3 μg/mL, 47.2 μg/mL, 154.2μg/mL 193.2 μg/mL A1, A2, A3 A4, respectively. Nanoparticles system Leishmania (V.) braziliensis. Red shown be potential candidates as intermediate preparation pharmaceutical dosage forms containing therapy against negligible diseases such leishmaniasis.
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