Identification and quantification of kynurenic acid in human brain tissue.
作者： Waldemar A. Turski , Masayuki Nakamura , William P. Todd , Barry K. Carpenter , William O. Whetsell
DOI: 10.1016/0006-8993(88)90815-3
关键词: Biochemistry 、 Endocrinology 、 Globus pallidus 、 Hippocampus 、 Thalamus 、 Caudate nucleus 、 Kynurenine aminotransferase II 、 Kynurenic acid 、 Central nervous system 、 Human brain 、 Internal medicine 、 Chemistry
摘要: Abstract Serial ion-exchange and high-performance liquid chromatography separations were employed for the tissue extraction purification of kynurenic acid (KYNA). Subsequently, compound isolated from postmortem human brain was unequivocally identified as KYNA by nuclear magnetic resonance mass spectrometric analyses. Regional distribution analyses revealed highest concentration (1.58±0.43pmol/mg tissue) in caudate nucleus with lower levels thalamus, globus pallidus, hippocampus, parietal cortex frontal cortex. Of structures examined, lowest (0.14±0.02pmol/mg found cerebellum.
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