Muscle relaxant action of excitatory amino acid antagonists

摘要: Spasticity has been defined as a motor disorder characterized by velocity-dependent increase in the resistance to passive stretch of muscles (Davidoff 1985) It develops after supraspinal or spinal lesions descending fibers. Subsequent these function different neuronal structures involved segmental reflex activity begins change at level cord. In spasticity there is indirect experimental evidence for hyperexcitability α-motoneurons and excitatory interneurons reduced Ia Ib axo-axonal synapses on primary afferent This results exaggerated mono- oligosynaptic dynamic reflexes, augmented polysynaptic flexor insufficient reciprocal autogenic postsynaptic inhibition, decreased presynaptic respectively (Ashby Wiens 1989; Delwaide Oliver 1988; Dietz 1987; lies Roberts 1986; Meinck et al. 1985; Thilmann 1991).