Intrathecal Injection of Antispastic Drugs in Rats: Muscle Relaxant Action of Midazolam, Baclofen, 2-Aminophosphonoheptanoic Acid (AP7) and Tizanidine
作者： M. Schwarz , T. Klockgether , L. Turski , K.-H. Sontag
DOI: 10.1007/978-3-642-72954-6_6
关键词: Spasticity 、 Medicine 、 Anesthesia 、 Baclofen 、 Tizanidine 、 Reflex 、 Motor disorder 、 Muscle relaxant 、 Muscle weakness 、 Midazolam
摘要: Spasticity has been defined as a motor disorder characterized by velocity-sensitive increase in the resistance to passive stretch of muscles, accompanied exaggerated tendon reflexes. This is thought result from hyperexcitability reflexes one component upper neurone syndrome [9, 51]. definition does not, however, apply all symptoms and complaints syndrome, for example flexor (flexor spasms), muscle weakness loss dexterity.
springer.com
sci-hub.st 参考文章(51)
W. Haefely, L. Pieri, P. Polc, R. Schaffner, General Pharmacology and Neuropharmacology of Benzodiazepine Derivatives Springer, Berlin, Heidelberg. pp. 13- 262 ,(1981) , 10.1007/978-3-642-67767-0_2
Lechoslaw Turski, Thomas Klockgether, Karl-Heinz Sontag, Paul L. Herrling, Jeffrey C. Watkins, Muscle relaxant and anticonvulsant activity of 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid, a novel N-methyl-D-aspartate antagonist, in rodents. Neuroscience Letters. ,vol. 73, pp. 143- 148 ,(1987) , 10.1016/0304-3940(87)90008-5
JH Kehne, DW Gallager, M Davis, Spinalization unmasks clonidine's alpha 1-adrenergic mediated excitation of the flexor reflex in rats The Journal of Neuroscience. ,vol. 5, pp. 1583- 1590 ,(1985) , 10.1523/JNEUROSCI.05-06-01583.1985
Tsutomu Kameyama, Toshitaka Nabeshima, Kiyoshi Matsuno, Akira Sugimoto, Comparison of α-adrenoceptor involvement in the antinociceptive action of tizanidine and clonidine in the mouse European Journal of Pharmacology. ,vol. 125, pp. 257- 264 ,(1986) , 10.1016/0014-2999(86)90035-X
J. Davies, R.H. Evans, P.L. Herrling, A.W. Jones, H.J. Olverman, P. Pook, J.C. Watkins, CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]d-AP5 binding sites on brain membranes and anticonvulsant activity Brain Research. ,vol. 382, pp. 169- 173 ,(1986) , 10.1016/0006-8993(86)90127-7
S. J. Potashner, Baclofen: effects on amino acid release and metabolism in slices of guinea pig cerebral cortex. Journal of Neurochemistry. ,vol. 32, pp. 103- 109 ,(1979) , 10.1111/J.1471-4159.1979.TB04516.X
W. Hunkeler, H. Möhler, L. Pieri, P. Polc, E. P. Bonetti, R. Cumin, R. Schaffner, W. Haefely, Selective antagonists of benzodiazepines. Nature. ,vol. 290, pp. 514- 516 ,(1981) , 10.1038/290514A0
J.S. Kroin, R.D. Penn, R.L. Beissinger, R.C. Arzbaecher, Reduced spinal reflexes following intrathecal baclofen in the rabbit. Experimental Brain Research. ,vol. 54, pp. 191- 194 ,(1984) , 10.1007/BF00235831
Lechoslaw Turski, Michael Schwarz, Waldemar A. Turski, Thomas Klockgether, Karl-Heinz Sontag, James F. Collins, Muscle relaxant action of excitatory amino acid antagonists Neuroscience Letters. ,vol. 53, pp. 321- 326 ,(1985) , 10.1016/0304-3940(85)90558-0
J. Davies, J.C. Watkins, Role of excitatory amino acid receptors in mono- and polysynaptic excitation in the cat spinal cord Experimental Brain Research. ,vol. 49, pp. 280- 290 ,(1983) , 10.1007/BF00238587