Differences in autophagy-related activity by molecular subtype in triple-negative breast cancer

摘要: The aim of this study was to assess the expression significant components autophagy including beclin-1, light chain (LC) 3A, LC3B, and p62 in molecular subtypes triple-negative breast cancer (TNBC) evaluate implications results. Tissues from 119 cases TNBC were used for a tissue microarray. Expression cytokeratin (CK) 5/6, epidermal growth factor receptor (EGFR), claudin 3, 4, claudin7, E-cadherin, androgen (AR), gamma-glutamyltransferase 1 (GGT-1) detected by immunohistochemical staining microarrays. According results, subclassified into basal-like type (CK5/6-positive and/or EGFR-positive group), apocrine (AR-positive GGT-1-positive low (claudin 3-, 4-, or 7-negative E-cadherin-negative mixed (having features more than two types), null (none above). Immunohistochemical autophagy-related markers LC3A, performed difference between clinicopathological parameters. TNBCs categorized as (36 patients, 30.3 %), (8 6.7 (16 13.4 (37 31.1 (22 18.5 %). nuclear higher other types (p = 0.008). beclin-1 0.039). LC3A LC3B showed no subtypes. Multivariate Cox analysis revealed that negative associated with shorter disease-free survival [p 0.012; odds ratio, 3.192; 95 % confidence interval (CI), 1.293–7.882] overall 0.009; 3.895; CI, 1.409–10.771). Among TNBC, others, which reflected activity.